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Home > Areas of Focus > Countermeasure Development
Countermeasure Development
  

Analyses and reviews of the strategies and programs aimed at developing countermeasures critical for responding to major biological threats, and of the necessary contributions of government, academia, and biopharma essential to improving national and international response capacity.

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Alliance for Biosecurity
A collaboration among the Center for Biosecurity and 13 pharmaceutical and biotechnology companies who seek to engage government in public-private partnerships
 

Recent Developments
Includes items from the Biosecurity Briefing and the Clinicians' Biosecurity Network.

Recent Developments - Countermeasure Development

Articles written by Center staff relating to countermeasure developments.

  1. WHO Reports Oseltamivir Resistance in Southern Hemisphere (08-25-2008)

    Biosecurity Briefing: On August 15, 2008, the World Health Organization (WHO) issued a report indicating that clinical samples from the 2008 influenza season provide evidence of a high degree of resistance to the antiviral drug oseltamivir (Tamiflu).
    Mon, 25 Aug 2008 16:32:51 GMThttp://www.upmc-biosecurity.org/website/biosecurity_briefing/archive/avian_pandemic_flu/2008/2008-08-25-whooseltamivirresistsohemisphere.html

  2. DTRA Awards Contract to Study Potential of Cethromycin as Broad-Spectrum Antibiotic (08-18-2008)

    Biosecurity Briefing: Advanced Life Sciences announced the award of a contract from the U.S. Dept of Defense Defense Threat Reduction Agency for advanced development of the antibiotic cethromycin as a potential broad-spectrum medical countermeasure.
    Mon, 18 Aug 2008 14:38:59 GMThttp://www.upmc-biosecurity.org/website/biosecurity_briefing/archive/countrmeasr_dev/2008/2008-08-18-dtracontractcethromycin.html

  3. Emergent BioSolutions Wins NIAID Grants, Sanofi to Acquire Acambis (08-04-2008)

    Biosecurity Briefing: Emergent BioSolutions, Inc., announced it has been awarded two grants from NIAID for the development of botulism and next-generation anthrax vaccine candidates. AP reported that sanofi-aventis will acquire vaccine-maker Acambis PLC.
    Mon, 04 Aug 2008 16:15:47 GMThttp://www.upmc-biosecurity.org/website/biosecurity_briefing/archive/agents_diseases/other/2008-08-04-emergentniaidsanofiacambis.html

 
[Biosecurity Briefing Archive | Clinicians' Biosecurity Network Report Archive]


Center Publications and Original Articles

Publications on Countermeasure Development

Articles written by Center staff relating to countermeasure developments.

  1. Biodefense Countermeasures: The Impact of Title IV of the US Pandemic and All-Hazards Preparedness Act

    Gronvall GK. Emerging Health Threats Journal. 2008;1:e3. doi: 10.3134/ehtj.08.003
    Fri, 07 Mar 2008 18:21:38 GMThttp://www.upmc-biosecurity.org/website/resources/publications/2008/2008-03-07-biodefensecountermeasure.html

  2. Letter to Editor: The FDA Animal Efficacy Rule and Biodefense

    Gronvall G, Trent D, Borio L, Brey R, and Nagao L on behalf of the Alliance for Biosecurity. Nature Biotechnology 25, 1084 - 1087 (2007) doi:10.1038/nbt1007-1084
    Mon, 01 Oct 2007 19:19:00 GMThttp://www.upmc-biosecurity.org/website/resources/publications/2007_orig-articles/2007-10-01-fdaanimalefficacyrulebiodefense.html

  3. Incentives for Biodefense Countermeasure Development

    Matheny J, Mair M, Mulcahy A, and Smith BT. Biosecurity and Bioterrorism. 2007;5(3).
    Sat, 15 Sep 2007 18:52:00 GMThttp://www.upmc-biosecurity.org/website/resources/publications/2007_orig-articles/2007-09-15-incentivesbiodefensecountermeasure.html

  4. Flexible Defenses Roundtable Meeting: Promoting the Strategic Innovation of Medical Countermeasures

    Gronvall GK, Matheny J, Smith BT, Mair M, Chamberlain A, Deitch S, Borio L, Inglesby TV, and O'Toole T. Biosecurity and Bioterrorism. 2007;5(3).
    Sat, 15 Sep 2007 18:46:00 GMThttp://www.upmc-biosecurity.org/website/resources/publications/2007_orig-articles/2007-09-15-flexibledefensesroundtablemeeting.html

  5. Biomedical Advanced Research and Development Authority (BARDA) Roundtable

    Gronvall GK, Smith BT, Matheny J, Mair M, Chamberlain A, Deitch S, Borio L, Inglesby TV, and O'Toole T. Biosecurity and Bioterrorism. 2007;5(2).
    Tue, 03 Jul 2007 20:00:00 GMThttp://www.upmc-biosecurity.org/website/resources/publications/2007_orig-articles/2007-07-03-bardameetingreport.html

  6. Removing Barriers to Global Pandemic Influenza Vaccination

    Gronvall GK, Borio L. Biosecurity and Bioterrorism. 2006;4(2).
    Thu, 15 Jun 2006 14:48:00 GMThttp://www.upmc-biosecurity.org/website/resources/publications/2006_orig-articles/2006-06-15-removingbarrierstoglobalpandemicfluvaccination.html

  7. Anthrax Countermeasures: Current Status and Future Needs

    Borio L, Gronvall GK. Biosecurity and Bioterrorism. 2005;3(2):102-112.
    Wed, 15 Jun 2005 12:57:00 GMThttp://www.upmc-biosecurity.org/website/resources/publications/2005_orig-articles/2005-06-15-anthraxcountermeasures.html

  8. Taking the Measure of Countermeasures: Leaders' Views on the Nation's Capacity to Develop Biodefense Countermeasures

    Gilfillan L, Smith BT, Inglesby TV, et al. Biosecurity and Bioterrorism. 2004;2(4):320-321.
    Wed, 15 Dec 2004 14:32:00 GMThttp://www.upmc-biosecurity.org/website/resources/publications/2004_orig-articles/2004-12-15-takingmsrofctrmsrs.html

  9. Smallpox Vaccine

    Henderson DA. In de Quadros CA , ed. Vaccines: Preventing Disease and Protecting Health. Washington, DC: Pan American Health Organization; 2004:281-286.
    Wed, 30 Jun 2004 15:07:00 GMThttp://www.upmc-biosecurity.org/website/resources/publications/2004_orig-articles/2004-06-30-smallpoxvaccine.html

  10. Vaccine Liability in the Era of Bioterrorism

    Mair JS, Mair M. Biosecurity and Bioterrorism. 2003;1(3):169-184.
    Mon, 15 Sep 2003 14:29:00 GMThttp://www.upmc-biosecurity.org/website/resources/publications/2003_orig-articles/2003-09-15-vaccineliability.html

  
Center Commentary

Recommendations for BARDA funding for FY2009 in a letter to Senator Burr (03-31-2008)

BARDA FY09 Advanced Development Cost Estimates for Medical Countermeasures Against Biological Threats (01-31-2008)

Ten Notable Publications of 2007 (01-10-2008)

  
Congressional Testimony and Briefings

Testimony on Countermeasure Development

Congressional testimony by Center staff regarding countermeasure development.

  1. Preparing for Bioterrorism: Project BioShield, BARDA and the Medical Countermeasure Enterprise (11-28-2007)

    A Capitol Hill briefing on the threat of bioterrorism, the status of developing new medicines and vaccines to counter biosecurity threats, and suggested four steps that the Congress can take to improve the current situation.
    Fri, 14 Dec 2007 19:30:15 GMThttp://www.upmc-biosecurity.org/website/resources/hearings/content/Hearings_2007/2007-11-28-prepbioterrorism/index.html

  2. Six Years After Anthrax: Are We Better Prepared to Respond to Bioterrorism? (10-23-2007)

    Testimony of Tara O'Toole before the Senate Committee on Homeland Security and Governmental Affairs.
    Tue, 23 Oct 2007 16:48:00 GMThttp://www.upmc-biosecurity.org/website/resources/hearings/content/Hearings_2007/20071023-sixyearsafteranthrax.html

  3. Hearing on "Project BioShield Reauthorization Issues" (04-06-2006)

    Testimony of Dr. Tara O'Toole before the Committee on Energy and Commerce, U.S. House of Representatives
    Thu, 06 Apr 2006 12:47:00 GMThttp://www.upmc-biosecurity.org/website/resources/hearings/content/Hearings_2006/20060406bioshldreauth.html

  4. Department of Health and Human Services Budget Priorities for FY 2003 (02-28-2002)

    Testimony of Dr. Tara O'Toole before the Committee on the Budget, U.S. House of Representatives
    Thu, 28 Feb 2002 13:23:00 GMThttp://www.upmc-biosecurity.org/website/resources/hearings/content/Hearings_2002/20020228FY2003budgetpriorities.html

  5. Hearing on FEMA's Role in Managing Bioterrorist Attacks and the Impact of Public Health Concerns on Bioterrorism Preparedness (07-23-2001)

    Testimony of Dr. Tara O'Toole before the Subcommittee on International Security, Proliferation and Federal Services, Committee on Government Affairs, U.S. Senate
    Mon, 23 Jul 2001 13:35:00 GMThttp://www.upmc-biosecurity.org/website/resources/hearings/content/Hearings_2001/20010723femarole.html


Center Events and Scenarios

Atlantic Storm.
Washington, DC. January 14, 2005.

  
Multimedia

Atlantic Storm Interactive

Slide lecture: "Polio Eradication: A Reconsideration of Strategy," a lecture delivered by Dr. D.A. Henderson for the John Snow Society (the 2007 Annual Pumphandle Lecture). Listen to the lecture | View the slides

Video of talk given by Tara O’Toole, MD, MPH, at the HHS Public Health Emergency Medical Countermeasures Enterprise (PHEMCE) Stakeholders Workshop on July 31, 2007. Dr. O’Toole was a member of the Academia/Science Panel addressing CBRN Medical Countermeasure Preparedness Efforts - Stakeholder Response.

Slide set: “Biosecurity Now and for the Long Run,” from the Thomas Glasser lecture delivered by Tom Inglesby, MD, on April 26, 2007, for the Overlook Hospital Foundation. Note: Statistics and facts included in the slides were current as of April 2007 and have not been updated.

  
U.S. Government Documents

U.S. government documents and reports related to countermeasure development

U.S. government documents – all topic areas

Biosecurity-related federal legislation

  
See Also

Biosecurity Briefing Archive: Countermeasure Development

Clinicians' Biosecurity Network Report Archive: Countermeasure Development

HHS MedicalCountermeasures.gov

Casting a Wider Net for Countermeasure R&D Funding Decisions. Klotz L. Biosecurity and Bioterrorism. 2007;5(4).

Security is More than Public Health: Commentary on ‘Casting a Wider Net for Countermeasure R&D Funding Decisions’. Epstein GL. Biosecurity and Bioterrorism. 2007;5(4).

Brief on the Global Biotechnology and Pharmaceutical Industries. Jason Matheny, 2007.

HHS Assistant Secretary for Preparedness and Response (ASPR) Biomedical Advanced Research and Development Authority (BARDA)

National Institutes of Allergy and Infectious Diseases (NIAID) Biodefense Research: National Institutes of Health (NIH)/NIAID

The Critical Path to New Medical Products Initiative: U.S. Food and Drug Administration (FDA)

Official Website of the of the Office of the Special Assistant for Chemical and Biological Defense and Chemical Demilitarization Programs: U.S. Department of Defense (DoD)

Advancing Science. Serving Society (AAAS) R&D Budget and Policy Program: Annual analysis of U.S. federal spending on research and development

American Society for Microbiology (ASM) Biodefense Conference: Annual ASM Biodefense and Emerging Diseases Research Meeting

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